I haven't tried it yet, but I've read that tea tree oil, or Melaleuca alternifolia oil, is an effective natural remedy for Pearly Penile Papules. Tea tree oil is a really lovely product from Australia--it tingles and smells kind of like eucalyptus, and I've used as a treatment for cuts and blisters, because it acts as an antimicrobial. Its also the main ingredient in the Derma Remedies product.